pentobarbital will lower the level or influence of trazodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital increases effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Warning/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers could increase metabolism of ifosfamide to its metabolite. Keep an eye on for amplified effects/toxicities if combined with CYP2B6 inducers.
pentobarbital will minimize the extent or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lessen the level or influence of losartan by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Unidentified.
pentobarbital will reduce the level or effect of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
Pursuing oral or parenteral administration, barbiturates easily cross the placental barrier and so are distributed in the course of fetal tissues with greatest concentrations located in the placenta, fetal liver, here and brain; fetal blood levels approach maternal blood ranges subsequent parenteral administration
pentobarbital will reduce the level or outcome of flurbiprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Unfamiliar.
pentobarbital will reduce the level or influence of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the level or influence of etonogestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Aged or debilitated patients may respond to barbiturates with marked despair, pleasure, and confusion; in a few sufferers, barbiturates continuously make pleasure rather then depression
pentobarbital will minimize the level or influence of duvelisib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration with a solid CYP3A inducer decreases duvelisib location beneath the curve (AUC), which can decrease duvelisib efficacy.
Watch Intently (three)pentobarbital will minimize the extent or impact of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Potent or moderate CYP3A4 inducers could enhance level of diazepam elimination; hence, efficacy of diazepam could possibly be diminished.
pentobarbital will minimize the extent or impact of ketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
If inducer is discontinued, take into consideration oliceridine dosage reduction and check for signs of respiratory melancholy.